Purchasing Generic Differin (Adapalene)

Active ingredient: adapalene 1.0 g
Select Doses: 15g
excipients: carbomer 934P (carbopol 974P®) - 4.5 mg; macrogol methyldextrose sesquistearate - 35.0 mg; glycerol - 30.0 mg; natural squalane - 60.0 mg; methyldextrose sesquistearate - 35.0 mg; disodium edetate - 1.0 mg; methyl parahydroxybenzoate - 2.0 mg; propyl parahydroxybenzoate - 1.0 mg; phenoxyethanol - 5.0 mg; cyclomethicone - 130.0 mg; sodium hydroxide - up to pH 6.5±0.2; purified water - up to 1.0 g.

Description of the dosage form
Cream for external use: brilliant white.

pharmachologic effect
Pharmacological action - comedolytic, anti-inflammatory.

Pharmacodynamics
Adapalene is a retinoid metabolite that acts on the pathological mechanism of development of Acne vulgaris, is a strong modulator of cell differentiation and keratinization and has comedolytic and anti-inflammatory activity.

The mechanism of action of adapalene is based on interaction with specific γ-receptors of epidermal skin cells. As a result of the action of adapalene, there is a decrease in the adhesion of epithelial cells at the mouth of the pilosebaceous follicle and a decrease in the formation of microcomedones.

Adapalene has an anti-inflammatory effect in vivo and in vitro, affecting inflammatory factors by inhibiting the migration of leukocytes at the site of inflammation, inhibits the chemotactic and chemokinetic responses of human polymorphonuclear leukocytes and suppresses the metabolism of arachidonic acid to inflammatory mediators, AP-1 factors and the expression of Toll-like receptors 2.

Pharmacokinetics
Absorption of adapalene through the skin is very low (about 4% of the applied dose). Excretion from the body occurs mainly through bile.

Indications
Acne of mild to moderate severity, incl. in the presence of comedones, papules and pustules.

Contraindications

Use during pregnancy and breastfeeding:

Pregnancy.
Clinical experience with topical use of adapalene during pregnancy is limited, however, available data in patients receiving the drug in early pregnancy do not indicate its negative effect on the course of pregnancy or the health of the fetus. Due to the limited nature of the available data, and also due to the possibility of minor penetration of adapalene through the skin, Differin should not be used during pregnancy. If pregnancy occurs, treatment should be discontinued.

Breastfeeding period.
No studies have been conducted on the penetration of the drug into animal or human breast milk after application to the skin. Because the systemic exposure of generic Differin for sale in breastfeeding women is negligible, no effects are expected in breastfed infants. Differin can be used during breastfeeding. To avoid contact of the infant with the drug, when using Differin® during breastfeeding, application to the breast area should be avoided.

Directions for use and doses
The cream/gel should be applied in a thin layer to acne-affected areas of the skin once a day before bedtime on clean, dry skin, avoiding contact of the cream with the eyes, lips, mucous membranes and corners of the nose. Noticeable clinical improvement develops after 4–8 weeks of treatment, persistent improvement after a 3-month course of treatment. Since alternation of therapy methods is common in the treatment of acne, after 3 months of drug therapy it is recommended to consult a doctor about further therapy.

Side effects
Differin may cause the following unwanted drug reactions.

Organ System Class (MedDRA)
Adverse drug reaction from the skin and subcutaneous tissues

Often
Dry skin, skin irritation, burning sensation, erythema

Infrequently
Contact dermatitis, discomfort, sunburn, itching, peeling skin, acne.

Frequency unknown
Allergic dermatitis (allergic contact dermatitis), skin tenderness, skin swelling, eyelid irritation, eyelid erythema, eyelid itching, eyelid swelling.

Post-registration surveillance data.

If any of the side effects indicated in the instructions are aggravated or any other side effects not listed in the instructions are noted, you should immediately inform your doctor.

Interaction
Absorption of adapalene through the skin is low, so its interaction with systemic drugs is unlikely. No interaction has been established with other drugs that can be used externally and simultaneously with Differin. When using Differin cream in the evening, in the morning you can use drugs for external treatment of acne, such as solutions of erythromycin (up to 4%) or clindamycin phosphate (1% in terms of base), or water-based benzoyl peroxide gels (up to 10%) , since these drugs do not cause mutual degradation or cumulative irritation.

However, other retinoids or drugs with a similar mechanism of action should not be used simultaneously with adapalene. The simultaneous use of Differin and peeling agents, abrasive cleansers, as well as products with a drying, astringent or irritating effect (aromatic or alcohol-containing products) is not recommended.

Where can I order Generic Differin?

Generic Differin (Adapalene) is an acne treatment and is therefore in good demand. We have left a link to a trusted (safe) online pharmacy where you can order/buy Generic Differin (Adapalene) over-the-counter at the best price. Online ordering of generics helps you save money without losing quality.
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Overdose
Symptoms: Excessive application of the drug to the skin will not lead to faster results or a more pronounced effect, but redness, peeling or discomfort may develop. Differin® Gel-Cream is intended for external use only.

Treatment: in case of accidental ingestion of even a small amount of the drug, the stomach should be rinsed and, if necessary, symptomatic therapy is carried out.

If you suspect a hypersensitivity reaction or severe skin irritation, discontinue use of the drug.

In some cases, depending on the degree of skin irritation, the number of applications may be reduced or treatment suspended until signs of irritation disappear. Resumption of treatment is possible after consultation with a doctor.

Avoid getting the cream in the eyes, mouth, corners of the nose and mucous membranes. If the drug accidentally gets on the mucous membranes of the eyes, rinse them with warm water.

The drug should not be applied to skin damaged as a result of injury (cuts or abrasions), sunburn or eczematous skin. In addition, it should not be used in patients with severe acne over large areas of the skin.

To avoid skin irritation when using adapalene, minimize exposure to sunlight and artificial UV irradiation, including sunlamps. If it is not possible to avoid exposure, it is recommended to use sunscreen and clothing to protect the treated skin areas.

The drug in the form of a cream is better suited for use on dry and fair skin. Can be used to treat acne on the face, chest or back. To get rid of this problem - you can buy Generic Differin (Adapalene) over the counter.

When using Differin®, it is possible to use cosmetics that do not have comedogenic or astringent properties.

Differin generic cream/gel contains methyl parahydroxybenzoate (E218) and propyl parahydroxybenzoate (E216), which may cause allergic reactions during or after treatment.

Impact on the ability to drive vehicles and operate machinery. Differin® cream does not affect the ability to drive vehicles or operate machinery.

Release form
Cream for external use 0.1%. 15 g in an aluminum tube, with an internal epoxyphenol coating, an aluminum membrane and a tightly screwed polypropylene cap with a tube punch. 1 tube along with instructions is placed in a cardboard box.